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Traditional treatments for AD, such as cholinesterase inhibitors and NMDA receptor antagonists, offer only modest symptomatic relief, while L-DOPA for PD primarily addresses motor symptoms, with limited efficacy against non-motor dysfunctions and progression

The thioredoxin system is composed of Trx proteins and Trx reductases (TrxR), in which the reduced form of Trx proteins (Trx(SH) 2 ) are disulfide reductases as they contain dithiol groups in their highly conserved active site (-Cys-Gly-Pro-Cys-) (45, 46)

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Individuals with a history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2, and those who are pregnant or breastfeeding, should avoid semaglutide

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The urine drains into a collection bag outside the body