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Contact your GP if you notice no improvement after 46 weeks of treatment, experience worsening neurological symptoms, or develop new unexpected symptoms

For an insulin syringe (U-100 scale, 100 units = 1 mL): For published preclinical context: mouse studies (Billon 2023, PMID 37739806) used 25 mg/kg IP twice daily a much higher per-kilogram dose than community injectable users typically describe

The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure

Understanding whether B12 injections require refrigeration depends on the specific formulation

This route is preferred when the goal is systemic peptide exposure rather than topical mucosal contact