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Int J Mol Sci 2019;20:1676

Thus, sertraline interferes with the function of the hypothalamicpituitarytesticular and hypothalamicpituitaryadrenal axes by affecting the wide distribution of serotonin receptors, thereby leading to reduced fertility in male rats (Figure 3)

Their presence has stimulated extensive in vitro and in vivo research on endogenous ligands, such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG)

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if you want to explore that relationship further, read our glutathione and vitamin C synergy guide

Apoptosis due to inflammation, ERS, and oxidative stress has long been thought to be the main cause of cell dysfunction