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Individuals carrying genetic variants linked to appetite dysregulation or reduced GLP-1 receptor sensitivity may experience more pronounced therapeutic response to semaglutide, making them excellent candidates regardless of their starting BMI

(2020) 21:e925020

Despite this, medical guidelines remain cautious

Similar effects are observed in keloid fibroblasts, where the adiponectin mimetic ADP355 suppresses ERK and p38 activation, reducing ECM accumulation [183]

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