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It is an honest discussion of when the conversation makes clinical sense, when it does not, and what realistic expectations look like in the patients for whom it might

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10.1016/j.biopsych.2017.09.021 136 SachdevaP.MehdiI.KaithR.AhmadF.AnwarM

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This surface expression is further reduced by mutation of the COPII-binding site, and also by the H1271K and the T1273A mutations that optimise the COPI binding site (Supplementary Fig