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911,13,14 Organelle swelling leads to cellular necrosis and the release of mitochondrial contents, such as apoptosis-inducing factor (AIF) and endonuclease G (EndoG), which in turn migrate to the nuclei and cause DNA fragmentation

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Nobiletin showed no obvious cytotoxicity in vivo (0.05% dietary concentration for 320 weeks) or in vitro (effective concentration 40 M), and cells resumed normal growth after withdrawal, with safety superior to existing chemotherapeutic agents (Goh et al., 2019)

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