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Semaglutide has been shown to potentiate the antitumor effect of levonorgestrel in EC models, including Ishikawa, Hec50 and KLE cells, as well as patient-derived organoids from grade 1 endometrial carcinomas

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Saxenda dosage starts from 0.6 mg subcutaneous injection once a day for the first week and increases to 1.2 mg, 1.8 mg, and 2.4 mg in the second, third and fourth week, respectively, if the patient can tolerate it