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[30] [31] A 2016 Australian study found that ME/CFS patients had significantly greater numbers of single nucleotide polymorphisms associated with the gene encoding for M3 muscarinic acetylcholine receptors

Patients using oral contraceptives should be aware that tirzepatide may reduce the effectiveness of these medications, particularly during initiation and dose escalation

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These roles are thought to be linked to its influence on signaling pathways such as those involving Vascular Endothelial Growth Factor (VEGF) and Transforming Growth Factor beta (TGF-)