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In Vivo Comparison: Rodent Hypertrophy Models In the synergist ablation (plantaris overload) model in male Sprague-Dawley rats, the gold standard for load-induced hypertrophy research: IGF-1 LR3 (1 g/kg i.m., every 48h, 14 days) versus Follistatin-344 (25 g/kg s.c., every 72h, 14 days) produce: Plantaris wet weight: IGF-1 LR3 overload +38% above sham-overload vehicle