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Critically, patients who discontinued treatment saw fat return to baseline within 26 weeks, confirming the effect requires continued use to maintain

Treatment will be deemed to have failed in these patients, and they will be further studied and treated outside the trial according to normal clinical practice

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These pores allow mtDNA to move from the matrix into the cytosol, a key event that triggers inflammatory signaling and further cellular deterioration (57) (Table 1)

Research shows that oxidative stress directly affects sleep quality

The MTHFR mutation can be inherited from one or both parents, affecting the MTHFR C677T or MTHFR A1298C genes specifically (3)