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Although occasionally linked to irritability or agitation, mechanistic investigations also suggest LEV can mitigate neuroinflammation, for instance, by suppressing transcription factors and restoring astrocytic gap junction coupling, potentially contributing to improved affect regulation (Kim et al., 2010

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Sian, J., et al

Cerebrospinal Fluid (CSF) Analysis CSF analysis remains a gold standard for assessing neurotransmitter imbalances, especially when investigating conditions like Alzheimer's disease

For example, macrolide antibiotics such as erythromycin and clarithromycin inhibit the enzyme CYP3A4, which metabolizes tacrolimus