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A., Darko, E

For example, a patient may need a different form because of an allergy to an inactive ingredient

J Clin Invest 2000, 105 (8), 10671075

Proc Natl Acad Sci USA 111:E404E413 Hemavathi UCP, Akula N, Young KE, Chun SC, Kim DH, Park SW (2009) Enhanced ascorbic acid accumulation in transgenic potato confers tolerance to various abiotic stresses

Each modification produces a molecule that is meaningfully different from the originator, performs better in some clinical dimension, and cannot be substituted at the pharmacy counter by a biosimilar of the original