Many antioxidant responses are controlled by the Nrf2, an evolutionary conserved transcription factor that is sequestered under basal conditions but upregulated acutely during oxidant attack
APMIS 122 , 7680 (2014)
Interestingly, SFN has a unique ability in Nrf2 activation, which enhances the expression of heme oxygenase-1 (HO-1) and nicotinamide adenine dinucleotide phosphate quinone oxidoreductase 1 (NQO1) (59, 67), thereby protecting neurons from 6-hydroxydopamine (6-OHDA), methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (68), amyloid (A) (69), and pro-inflammatory cytokines (70, 71)
Future experiments should focus on optimisation by increasing the amount of protein for the reaction
In theory, consistent follicle support helps melanocytes resist age-related decline for longer
However, they are fundamentally different compounds that work through distinct biological mechanisms