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Second, we assessed each drug in expanded populations reflective of patients routinely seen in clinical practice

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5 For example, recent preclinical and clinical observations highlight the role of gut-derived peptides such as GIP, GLP-2, and to a lesser extent, GLP-1 in the maintenance of overall skeletal health ( Figure 2 ), 6,7,8 opening new avenues for the understanding and potential treatment of bone disorders

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This risk is especially relevant for patients who were already at risk for deficiencies before starting treatment