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conducted a randomized controlled clinical trial with 31 subjects, testing antioxidant capacity before and after using FRAP, DPPH, and ABTS, and found that baobab fruit extracts significantly reduced the incremental glycemic AUC while demonstrating considerable suppression of reactive oxygen species and antioxidant activity (Rita et al., 2022)
Oral pills, conversely, must navigate the digestive system, resulting in significantly lower absorption rates (estimated at 1-2%)
The largest effect size of any non-surgical metabolic intervention in clinical trial history
Nrf2/ARE target genes code for several mediators of the antioxidant response, including -GCL, NAD(P)H quinone oxidoreductase 1 (NQO-1), heme oxygenase-1 (HO-1), catalase, and superoxide dismutase (SOD)
