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Future Directions and Research Opportunities Triple Agonism and Beyond The success of dual agonism has stimulated interest in triple agonism approaches that add glucagon receptor activation to GIP and GLP-1 targeting

who were treated for obesity between May 2022 and January 2026

Incretin medications work by mimicking hormones the gut produces naturally after eating

Dubanewicz says

This warning applies to all medications containing semaglutide, including Wegovy, as well as other GLP-1 agonists like Ozempic and Rybelsus, which are used for Type 2 diabetes (and off-label for weight loss)

Kelley DS, Adkins Y, Laugero KD