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IGF-1 LR3 directly stimulates satellite cell activation, proliferation, and fusion, processes essential for muscle regeneration and growth

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The most prevalent form, Distal Symmetric Polyneuropathy (DSPN), results from oxidative damage to Schwann cells and sensory neurons in peripheral nerves (Panou et al., 2025)

Other indirect inhibitors targeting inflammasome assembly or upstream signaling cascades may also mitigate mtDNA-mediated inflammation [106]

More importantly, in this study, we discovered that the changes in the protein levels of GLUT1 and GLUT6 are consistent with the role of mature SREBP2 as a transcription factor (Fig