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Understanding treatment duration planning is critical for setting realistic expectations

Activated protein C downregulates SOD1 in SOD1 mutant mice, reduces blood-spinal cord barrier permeability, and slows disease progression [130]

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However, as crude as LD50 may be regarded by the purist, it is a useful guide to determine acute toxicity and is the technique currently favoured in chemical safety data sheets (section 11, Toxicology)

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