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When the anemia is severe and the red blood cell count is extremely low, blood transfusions may be necessary for the first couple of days until the vitamin B 12 injections begin working

The mean value of their scores is presented

The synergistic combination of Bromelain and Lecithin induces fat cell breakdown through enzymatic action and membrane disruption, promoting natural fat elimination

4 Materials and methods 4.1 Cell culture and in vivo experiments 4.1.1 Cell lines Four human NB cell lines were used in this paper: Be(2)-C (MNA), IMR5-/75-shMYCN (29) (MNA, doxycycline-inducible shRNA targeting MYCN, resulting in MYCN downregulation), IMR-32 (MNA), and SH-SY5Y/6TR(EU)/pTrex-Dest-30/MYCN (non-MNA, doxycycline-inducible transgene, resulting in MYCN overexpression)

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At low concentrations, it increases MMP1 and MMP2, which break down damaged or disorganized collagen and elastin