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While PDE5 inhibitors are effective for many patients, some men experience inadequate response or persistent low libido, prompting increased clinical interest in centrally acting therapies such as PT-141

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Those who experience chest pain, troubled breathing, difficulty swallowing, increased heart rate, or unusual tiredness should contact their doctor immediately as these are considered to be severe symptoms and life threatening complications

In rare cases, hospitalization might be needed for proper treatment and monitoring

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Therefore, homozygous and heterozygous carriers of the UGT1A3*5 allele required a higher dose of VPA to reach the therapeutic range in plasma (as measured by therapeutic drug monitoring) in the range of 50100 g/mL [72]