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Mechanistic investigations often pair 5-Amino-1MQ treatment with transcriptomic and proteomic analyses to map the downstream signaling changes that accompany NNMT inhibition, establishing a fuller picture of the enzyme's regulatory network

To determine the kinetics of chaining, a time course of infection was performed from 2496 hpi

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In this same work, it is described that curcumin could inhibit HDACs through a mechanism related to the inhibition of the NF-kB pathway in cancer stem cells (Marquardt et al., 2015)