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Unmethylated CpG-oligonucleotides (CpG-ODNs) treatment successfully induces Th1 immunity and reduces existing Th2 responses, consequently modifying the immune responses to alleviate allergic symptoms associated with asthma [78]
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In skin specifically, GHK-Cu has been extensively studied for its ability to increase collagen and elastin production, improve skin thickness and elasticity, reduce fine lines and wrinkles, improve skin firmness, reduce photodamage, reduce hyperpigmentation, and accelerate wound healing
Fifth, redesign trials as mechanism-anchored: use biomarker gates for enrollment and co-primary endpoints that pair mechanistic change (e.g., Prx cycling, 2-OH-E, LIP shifts) with clinical benefit, avoiding the trap of ROS lowering without outcome (Drakulic et al
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