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Diabetes Obes Metab 20(2):362369 Bunck MC, Diamant M, Cornr A, Eliasson B, Malloy JL, Shaginian RM et al (2009) One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial

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Trulicity's cardiovascular protection appears to operate through additional mechanisms beyond glycemic control including anti-inflammatory effects, improved blood vessel function, and reductions in blood pressure and triglycerides though the full picture of how dulaglutide reduces cardiovascular events is still being studied