Psychological & Physiological Dependence Patients may develop a psychological or physiological reliance on GLP-1 medications, complicating the discontinuation process
While natural GLP-1 rarely causes problems, pharmaceutical GLP-1 agonists commonly cause gastrointestinal side effects including nausea, vomiting, diarrhea, and constipation, particularly during dose escalation
This overlap can complicate management and may require closer monitoring
Dietary protein, weight loss, and weight maintenance
Changes in pro-C3 have also been shown to correlate with changes in fibrosis stage in patients with T2D and MASLD after 18 months of treatment with pioglitazone, vitamin E or placebo 37
A new addition to the GLP-1 medication group is retatrutide