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The legal standard for patent misuse or antitrust violation is high, however, and companies have generally been able to maintain thickets without successful challenge

Doi:10.1038/s41591-022-02026-4 Lincoff AM, Brown-Frandsen K, Colhoun HM, et al

Even optimistic forecasts struggled to keep pace with what followed

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The emergence of pancreatitis in this population raises questions about whether the drugs risk-benefit profile was appropriately communicated and whether additional warnings should have been implemented as prescribing patterns shifted