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they may also represent the severity and progression of the disease

Neurodevelopmental effects of opioids in preterm infantsa systematic review and meta-analysis of randomised and observational studies

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Reduced GS activity compromises astrocytic homeostatic capacity, permitting extracellular glutamate accumulation and impairing neurotransmitter recycling, a dual pathology exacerbating both excitotoxicity and inhibitory network instability [42]

Both medications reduce appetite through different mechanisms: Wegovy through GLP-1-mediated satiety signals and delayed gastric emptying, and stimulants through central effects on appetite centres