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Cold fluid is more viscous and can create what some people call "thermal shock" against warm tissue

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For this reason, many people take methylcobalamin along with either hydroxocobalamin, cyanocobalamin, or adenosylcobalamin to ensure coverage of both coenzyme pathways

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Specifically, 132 trials (50.3%) enrolled fewer than 50 participants, and 56 trials (21.3%) had sample sizes between 50 and 100 (Supplementary Fig