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By incorporating non-pharmacological methods and considering pharmacological alternatives with a favorable safety profile, healthcare providers can offer holistic, patient-centered pain management strategies

J Agric Food Chem 59:80218027 Chueh WH, Lin JY (2012) Protective effect of berberine on serum glucose levels in non-obese diabetic mice

But losing 17% of body weight is a substantial weight loss for many patients

At the same time, the incidence of diabetic nephropathy, although reduced compared to 20 years ago, is stabilized in recent years, and the incidence of end-stage renal disease (due to reduced cardiovascular mortality and increased life expectancy) is increasing [64]

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Lipid-lowering therapy The therapeutic benefits of cholesterol management and statin therapy in preventing atherosclerotic CV disease are well established