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GLP-1 MODULATES LIPID METABOLISM GLP-1 Modulates fat synthesis in the liver GLP-1 modulates hepatic lipolysis GLP-1 modulates liver cholesterol metabolism GLP-1 modulates adiposynthetic and differentiation GLP-1 modulates fat browning Clinical application of GLP-1 in obesity Obesity is a major health problem worldwide

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doi: 10.2337/diacare.27.11.2628 213 DeFronzoRARatnerREHanJKimDDFinemanMSBaronAD

No doubt, these data will likely lead to an indication in the label for the treatment of knee osteoarthritis once approved." Kenneth Custer, PhD, Eli Lilly Executive VP "People with obesity and knee osteoarthritis often live with pain and restricted mobility, and may eventually require total joint replacement

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