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This activity is mainly achieved by its direct hypothalamic activity on the arcuate nucleus (ARC)

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Specifically, we seek to evaluate the effects of PCOS on DNA methyltransferase (DNMT) gene expression (DNMT1, DNMT3a, DNMT3b), oxidative stress markers (glutathione peroxidase, catalase, superoxide dismutase, glutathione reductase, glutathione, and malondialdehyde), and trace element levels (zinc, copper, magnesium, and Fe) in ovarian tissue, serum, and liver

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B12 circulates in the blood bound to transport proteins (particularly transcobalamin) and binding proteins (such as haptocorrin)

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