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Neither route has human clinical trial evidence

have found that melatonin is able to attenuate MUC5AC secretion and gene expression in H292 cells and a murine model of asthma via intraperitoneal treatment [71, 72]

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In some embodiments, the ratio of a thermoreversible poloxamer to a thickening agent in a formulation that has a pH as described herein is about 40:1, about 35:1, about 30:1, about 25:1, about 20:1, about 15:1, about 10:1, or about 5:1