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GLP-1 receptors are present in brain regions controlling sleep-wake cycles, so activation can influence neurotransmitter balance and circadian rhythm

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Starting with lower doses produces meaningful metabolic effectsincluding improved appetite regulation, enhanced insulin sensitivity, and modest weight reduction in the first monthwhile allowing patients' bodies to acclimate to GLP-1 signaling

J Affect Disord 370: 321327

The cardiovascular outcomes data further supports metabolic improvement: patients on GLP-1 therapy show reduced inflammation markers, better cholesterol profiles, and lower blood pressureall hallmarks of improved insulin sensitivity