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Inhibiting DHODH activity leads to a reduction in COQ10 levels, compromising antioxidant capacity and increasing susceptibility to lipid peroxidation and ferroptosis [13]
However, amino acid analogs are unsuitable for clinical use due to their low affinity, lack of specificity, and toxicity 87
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GLP-1 medications, such as Semaglutide and Tirzepatide, target these underlying pathways by enhancing satiety signals and improving insulin response, allowing the body to sustain weight reduction without severe deprivation
It is important for healthy bone development in PWS because many individuals develop low bone mineral density during adolescence and adulthood due to hormone abnormalities
During aggressive weight loss, this systemic support addresses the widespread tissue remodeling occurring as fat stores deplete and lean tissue adapts to new metabolic demands
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