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Arabidopsis glutathione reductase 2 is indispensable in plastids, while mitochondrial glutathione is safeguarded by additional reduction and transport systems

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When cost efficiency is a priority, precursor-based strategies such as NAC + glycine may achieve similar biological outcomes while maintaining competitive retail pricing

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Repeated stricture formation is also possible, leaving only less desirable treatment options, such as long-term percutaneous gastrostomy tube feeding or surgery