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Moreover, glycyrrhizin was found to protect melanocytes from oxidative stress by inducing the nuclear translocation of Nrf2 in human melanocytes, thus inducing the expression of HO-1, an antioxidant enzyme responsible for heme degradation [81]

However, the choice of such cosolvents and solvents can significantly influence the effective bioavailable concentration of the compound, thereby affecting pharmacokinetic and pharmacodynamic outcomes

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