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In addition to the above, DSIP has demonstrated some potential as a therapy for other health concerns, at least in animal studies

doi: 10.1016/j.joca.2021.06.010 179 LuSSongYLuoRLiSLiGWangKet al

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These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue

Hickey 2010