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The decision to terminate the clinical development of Lotiglipron was based on the pharmacokinetic data from the clinical Phase 1 drug-drug interaction studies (NCT05671653 and NCT05788328), as well as the laboratory measurements of elevated transaminases in these Phase 1 studies and the ongoing Phase 2 study (NCT05579977)

Storage recommendations here come from general bacteriostatic water peptide compounding standards (USP General Chapter ) and established GLP-1 biologic handling practices

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Mol Cell 4: 469477 Fratelli M et al

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