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GLP-1 analogs and GLP-1R agonists can exert hypoglycemic effects and reduce weight

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Others experience fatigue as their bodies adjust to reduced caloric intake

Physical activity works synergistically with semaglutide GLP-1 to promote weight loss and improve glucose regulation

Obese mouse models (Coskun 2022) show basal energy expenditure +8-12% vs vehicle, a major contributor to the magnitude of weight loss observed in phase II clinical trials

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