Therapeutic doses for weight loss range from 0.25 mg to 2.4 mg weekly, while animal studies show severe toxicity only at doses 50 to 100 times higher than standard human treatment levels
In NSCLC, carbon monoxide (CO) directly triggers ferroptosis through the ROS/GSK3/GPX4 axis, resulting in the accumulation of LOOH (91)
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Animal-model evidence is strong: rat ulcerative colitis, ileoileal anastomosis (Vuksic 2007), gastric-mucosal protection studies (Sikiric multi-paper)
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Um, and I've looked at so many drugs that have even gone on the market, have been taken off the market, and you, a lot of stuff you can't really see as an effect until you test it on a wide range of people in a wide range of situations