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This is mechanistically demonstrated in breast cancer models, where SFN, by activating the Nrf2 pathway, reduces the secretion of prostaglandin E2 (PGE2) from tumor cells, thereby triggering MDSCs to switch from an immunosuppressive to an immunogenic phenotype and inhibiting their expansion (76)

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Journal Translational Research 11 (10), 64136421

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Most experts suggest either starting with a loading phase dosage of 20 g/day for 5-6 days then dropping to a maintenance dose of 2-3 g/day 12 , or simply taking 3-5 g/day consistently without loading