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gastrointestinal irritation, headaches, insomnia, and mood changes are most common, though rare cases of kidney and liver damage and blood disorders have been reported

All significant weight loss interventions carry some risk of lean mass reduction alongside fat loss

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32 A fatty acid chain attached to Lys 20 in tirzepatide may boost the GLP-1 activity while the GIP activity remains unaffected

The same drug that might give you a headache during the first few weeks of treatment could, through entirely different mechanisms, protect your brain from the neuroinflammatory cascade that drives true migraine attacks

The GLP-1 based therapies were also found to be associated with significant reductions in the serum levels of total cholesterol, LDL-cholesterol and triglycerides