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While diet should be optimised to provide a diverse array of antioxidant nutrients, supplementation may be required to address shortfalls that are common in Western-style diets
Intriguingly, genetic variations with reduced IIS due to SNPs of interacting components of the IIS cascades ( GH1, IGF1, IGF1R, IRS1, FoxO1A, FoxO3A ) and have been associated with increased longevity [30, 31]
To the uninformed, it may seem like being overweight is natural and healthy
Always consult peer-reviewed literature for guidance
doi: 10.1074/jbc.M111.310342