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Zonisamide in the treatment of binge-eating disorder: an open-label, prospective trial

According to FDA-approved prescribing information, gastrointestinal adverse effects occur commonly with these medications, with nausea reported in 16-44% of patients, vomiting in 6-24%, and abdominal pain or distension in 5-18%, depending on the specific medication and dosage

The sample size was relatively small at 307 participants

6 weeks-20-25 lbs

The most likely causes include fat and muscle loss, hormonal fluctuations, dehydration, and microbiome shifts rather than a direct drug effect

Testosterone signals through mTOR and androgen receptor to induce muscle hypertrophy