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J Clin Invest 133(3):e167952 [DOI] [PMC free article] [PubMed] [Google Scholar] 16.Kusminski CM, Perez-Tilve D, Mller TD, DiMarchi RD, Tschp MH, Scherer PE (2024) Transforming obesity: The advancement of multi-receptor drugs

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For those with preserved ejection fraction (HFpEF), GLP-1 medications reduced the composite of cardiovascular death or worsening heart failure events by 32% 15

Additionally, GIP directly stimulates lipogenesis, while GLP-1 indirectly promotes lipolysis, collectively maintaining healthy adipocytes, reducing ectopic fat distribution, and increasing the production and secretion of adiponectin from adipocytes

Biostimulators like Sculptra work differently from traditional fillers

In 2024 the journal Diabetes named it as a classic paper