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The activation of GHSR modulates several intracellular signaling pathways and exhibits different endocrine and non-endocrine effects (16)

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These may include: Blood sugar abnormalities High blood pressure Headaches and nausea Hormonal imbalances Muscle damage Long-term misuse may increase the risk of blood clots, bone loss, and certain cancers

sCT when bound to AMYRs induce a CT-like receptor conformation 15 , while P32Y substitutions of CT analogues are also detrimental to affinity and potency at AMYRs 18,19

The Blood Service Biobank personnel are acknowledged for organizing research project-specific sample collection in blood donation activities and Aurea biobank thanked for samples of diseased individuals