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In PWS patients, this mechanism theoretically targets the same hypothalamic dysfunction that drives hyperphagia, making GLP-1 therapy a biologically rational option to explore

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Patients with a history of small-bowel obstruction or fistulizing disease should consult their gastroenterologist before initiating any GLP-1, as slowed gastric emptying and reduced motility may pose mechanical risks

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J Mol Endocrinol 40: 93-100, 2008