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Moreover, the inhibition percent (% inhibition) of sample B was higher than inhibition percent of sample A and the % inhibition of sample D was higher than % inhibition of sample C this may be due to different of concentration as El-Atawy et al

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Other common grade 3 or 4 AEs were fatigue (15%) and anorexia (6%)

Prostaglandin E2 (PGE2), as a key immunosuppressive mediator, can suppress the activity of CTLs [92], dendritic cells [91], and NK cells [93], thereby interfering with anti-cancer immune responses