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Clinical trials demonstrate 15-20% body weight reduction with semaglutide and tirzepatide over 68 weeks
The most commonly reported side effects include headache, dry mouth, and insomnia, with these symptoms affecting a substantial portion of patients
GSK3 overexpression abrogates the protective effects of semaglutide, while GSK3 knockdown mimics its actions, establishing GSK3 as a mediator of GLP-1