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Here are the core points to remember: Cancer Risk: While rodent studies showed an increase in rare thyroid tumours, large-scale human studies (including the 2022 Hu et al

24 Limitations and future directions Despite the promising results, several limitations should be acknowledged

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The Optical Coherence Tomography work by Hubinger and colleagues documented that microneedle-induced channels close measurably within hours of insertion, with full barrier restoration on the order of 24 hours for shallow channels [4]