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The Journal of Investigative Dermatology

The effect of glutathione and vitamins A, C, and E on acute skin flap survival

Since GSH is not carried inside the cell, exogenously administered GSH is most likely to act by increasing plasma GSH levels reducing luminal oxidative stress and increasing NO bioavailability in patients with endothelial dysfunction (220)

In addition to KEAP1, which is the main negative regulator of NRF2 protein stability, many other factors which negatively regulate NRF2 have been discovered and characterized

4F, Supplementary Table 4)

The most common before-and-after improvements include enhanced radiance, reduction in tanning, improved skin clarity, and a more even complexion